Business Details
40 Years
experience
Preclinical CRO Services for Drug Development
TSRL is a preclinical contract research organization (CRO) dedicated to advancing drug development for pharmaceutical, biotech, and academic teams. Founded in 1986, we specialize in integrated services including formulation development, bioanalysis, PK/ADME, toxicology, and strategic consulting. Our 7,200 sq. ft. facility in Ann Arbor, Michigan, features 5,000 sq. ft. of wet lab space with analytical chemistry, formulation suites, and in vitro/in vivo testing capabilities. We prioritize scientific clarity, collaboration, and transparency to generate high-quality data aligned with regulatory and development goals. Our team of experienced pharmaceutical scientists and commercialization experts provides tailored solutions to de-risk programs and accelerate progress from lead to clinic.We support non-dilutive funding strategies, including SBIR grants, with a 40% success rate over the past decade. TSRL partners with academic institutions and startups to bridge the translational gap between discovery and clinical readiness. Our AAALAC-accredited animal facilities and cross-functional coordination ensure robust study designs and reliable documentation. We focus on delivering practical, science-driven support to transform early-stage therapeutics into viable programs. With decades of experience and a track record of securing $21 million in awards, TSRL remains committed to innovation and excellence in drug development.
Services
Formulation Development
Bioanalysis
PK/ADME
Toxicology
Strategic Consulting
Drug Delivery Technology
Partnering
Details
- Year established: 1986
Highlights and features
- Our scientists have decades of hands-on drug development experience since 1986.
- We provide on-site wet lab space and AAALAC-accredited animal facilities.
- Tailored development paths align with project milestones and regulatory needs.
- Proven success in securing $21 million in non-dilutive funding awards.
- Cross-functional teams integrate formulation, bioanalysis, and PK expertise.
Associations and certifications
- AAALAC International
Services
Formulation Development
Our formulation development services optimize drug solubility, stability, and delivery through tailored approaches. We address compliance and convenience challenges using advanced techniques to meet specific therapeutic needs. Our team ensures formulations align with regulatory requirements and clinical goals.
Bioanalysis
We provide high-sensitivity bioanalysis using HPLC and LC-MS/MS for pharmacokinetic, safety, and toxicology studies. Our methods ensure accurate drug quantification to support regulatory submissions and decision-making. Services include method development, validation, and sample analysis for diverse compounds.
PK/ADME
Our PK/ADME studies assess drug absorption, distribution, metabolism, and elimination. We design experiments to generate data for regulatory submissions and optimize dosing regimens. Expert analysis supports early toxicology insights and development strategy planning.
Strategic Consulting
We offer strategic consulting to align preclinical programs with regulatory and commercial goals. Services include gap analysis, funding strategy, and grant co-development. Our experts strengthen applications for SBIR and other non-dilutive funding mechanisms.
Drug Delivery Technology
We support novel drug delivery technologies, including microneedle patches, to improve compound stability and patient compliance. Our team addresses formulation challenges for innovative delivery methods, ensuring compatibility with clinical and commercial requirements.
Questions
What preclinical services does TSRL offer?
TSRL offers formulation development, bioanalysis, PK/ADME, toxicology, strategic consulting, and drug delivery technology support for early-stage drug candidates.
How does TSRL support non-dilutive funding?
TSRL helps secure SBIR grants and other non-dilutive funding with a 40% success rate, providing grant co-development and commercialization strategy expertise.
What makes TSRL's approach unique?
TSRL combines scientific expertise with hands-on drug development experience, offering tailored solutions, AAALAC-accredited facilities, and integrated cross-functional services.
Can TSRL assist with academic partnerships?
Yes, TSRL partners with academic institutions to bridge the gap between discovery and clinical readiness through preclinical services and business planning support.
Where is TSRL located?
TSRL is based in Ann Arbor, Michigan, with a 7,200 sq. ft. facility featuring 5,000 sq. ft. of wet lab space for drug development research.
