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Fresno is a city in California, USA, the county seat of Fresno County, and the biggest inland city in the state. Fresno is situated in Central California between Los Angeles and San Francisco. Fresno had an estimated population of 490, 847 as of January 27, 2009, making it the 5th-biggest city in California. 5] It is situated in the heart of the expansive San Joaquin Valley in the Central Valley, 6] approximately 200 miles (322 km) N of Los Angeles, and 170 miles (274 km) S of the state capital, Sacramento.